- Corrigendum: The authors found errors in our published article: Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
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Ho-Jin Kang, Eun-Jeong Kim, Byoung-Gwon Kim, Chang-Hun You, Sang-Yong Lee, Dong-Il Kim, Young-Seoub Hong
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J Prev Med Public Health. 2012;45(5):333-333. Published online September 28, 2012
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DOI: https://doi.org/10.3961/jpmph.2012.45.5.333
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Corrects: J Prev Med Public Health 2012;45(4):251
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Summary
- Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
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Ho-Jin Kang, Eun-Jeong Kim, Byoung-Gwon Kim, Chang-Hun You, Sang-Yong Lee, Dong-Il Kim, Young-Seoub Hong
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J Prev Med Public Health. 2012;45(4):251-258. Published online July 31, 2012
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DOI: https://doi.org/10.3961/jpmph.2012.45.4.251
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Correction in: J Prev Med Public Health 2012;45(5):333
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The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. MethodsHypermethylation profiles of nine genes (RASSF1, APC, p16INK4a, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction. ResultsNine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of p16INK4a and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, E-cadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2. ConclusionsThis study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.
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- Relationship Between Blood Mercury Concentration and Waist-to-Hip Ratio in Elderly Korean Individuals Living in Coastal Areas
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Chang-Hun You, Byoung-Gwon Kim, Jung-Man Kim, Seung-Do Yu, Yu-Mi Kim, Rock-Bum Kim, Young-Seoub Hong
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J Prev Med Public Health. 2011;44(5):218-225. Published online September 28, 2010
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DOI: https://doi.org/10.3961/jpmph.2011.44.5.218
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This study investigated the relationship between the blood mercury concentration and cardiovascular risk factors in elderly Korean individuals living in coastal areas. MethodsThe sample consisted of 477 adults (164 males, 313 females) aged 40 to 65 years who visited a Busan health promotion center from June to September in 2009. The relationship between blood mercury concentration and cardiovascular risk factors including metabolic syndrome, cholesterol profiles, blood pressure, body mass index (BMI), waist circumference and waist-to-hip ratio (WHR), was investigated. Variables related to blood mercury concentration were further evaluated using multiple regression analysis. ResultsThe blood mercury concentration of the study population was 7.99 (range, 7.60 to 8.40) µg/L. In males, the blood mercury concentration was 9.74 (8.92 to 10.63) µg/L, which was significantly higher than that in females (7.21, [6.80 to 7.64] µg/L). The blood mercury concentration of the study population was related to several cardiovascular risk factors including low-density lipoprotein (LDL) cholesterol (p=0.044), high-density lipoprotein (HDL) cholesterol (p=0.034), BMI (p = 0.006), waist circumference (p = 0.031), and WHR (p < 0.001). In males, the blood mercury concentration was significantly correlated with WHR in the multiple regression analysis. ConclusionsIn males, the blood mercury concentration was related to waist-to-hip ratio, which is a central obesity index and cardiovascular risk factor. Our finding suggests that cardiovascular disease risk in males was increased by mercury exposure via an obesity-related mechanism.
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Citations to this article as recorded by - Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches
Airton C. Martins, Beatriz Ferrer, Alexey A. Tinkov, Samuel Caito, Romina Deza-Ponzio, Anatoly V. Skalny, Aaron B. Bowman, Michael Aschner
Toxics.2023; 11(8): 670. CrossRef - Effect of Mixture of Heavy Metals on Metabolic Syndrome and Its Components in Individuals ≥ 18 Years of Age: From Big Data to Molecular Mechanisms Involved
Hai Duc Nguyen, Hojin Oh, Min-Sun Kim
Exposure and Health.2023; 15(4): 773. CrossRef - Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
Food Risk Assess Europe.2023;[Epub] CrossRef - Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
Environmental Research.2022; 204: 111888. CrossRef - The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age
Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
Biological Trace Element Research.2022; 200(8): 3554. CrossRef - Differential fat accumulation in early adulthood according to adolescent‐BMI and heavy metal exposure
Larissa Betanzos‐Robledo, Martha M. Téllez‐Rojo, Hector Lamadrid‐Figueroa, Ernesto Roldan‐Valadez, Karen E. Peterson, Erica C. Jansen, Nil Basu, Alejandra Cantoral
New Directions for Child and Adolescent Development.2022; 2022(181-182): 37. CrossRef - Toenail mercury levels positively correlate with obesity and abdominal obesity among Korean adults
Jimin Jeon, J. Steven Morris, Kyong Park
Journal of Trace Elements in Medicine and Biology.2021; 64: 126678. CrossRef - Assessment of the hyperlipidemia risk for residents exposed to potential emitted metals in the vicinity of a petrochemical complex
Chih-Hsiang Shun, Tzu-Hsuen Yuan, Shou-Hung Hung, Yen-Po Yeh, Yi-Hsuan Chen, Chang-Chuan Chan
Environmental Science and Pollution Research.2021; 28(22): 27966. CrossRef - Association between Dyslipidemia and Mercury Exposure in Adults
Purum Kang, Hye Young Shin, Ka Young Kim
International Journal of Environmental Research and Public Health.2021; 18(2): 775. CrossRef - Assessment of Lead and Mercury Exposure Levels in the General Population of Korea Using Integrated National Biomonitoring Data
Jeong-Wook Seo, Young-Seoub Hong, Byoung-Gwon Kim
International Journal of Environmental Research and Public Health.2021; 18(13): 6932. CrossRef - Mercury and Atherosclerosis: Cell Biology, Pathophysiology, and Epidemiological Studies
Tahereh Farkhondeh, Reza Afshari, Omid Mehrpour, Saeed Samarghandian
Biological Trace Element Research.2020; 196(1): 27. CrossRef - Association of Blood Mercury Level with the Risk of Depression According to Fish Intake Level in the General Korean Population: Findings from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2013
Kyung Won Kim, Sundara Raj Sreeja, Minji Kwon, Ye Lee Yu, Mi Kyung Kim
Nutrients.2020; 12(1): 189. CrossRef - Mercury Exposure and Associations with Hyperlipidemia and Elevated Liver Enzymes: A Nationwide Cross-Sectional Survey
Seungho Lee, Sung-Ran Cho, Inchul Jeong, Jae Bum Park, Mi-Yeon Shin, Sungkyoon Kim, Jin Hee Kim
Toxics.2020; 8(3): 47. CrossRef - The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
Soo Ho Sohn, Han Cheol Heo, Seongmin Jo, Chulyong Park, Joon Sakong
Annals of Occupational and Environmental Medicine.2020;[Epub] CrossRef - Aluminium levels in hair and urine are associated with overweight and obesity in a non-occupationally exposed population
Alexey A. Tinkov, Margarita G. Skalnaya, Jan Aaseth, Olga P. Ajsuvakova, Michael Aschner, Anatoly V. Skalny
Journal of Trace Elements in Medicine and Biology.2019; 56: 139. CrossRef - The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013
Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim
Korean Journal of Pediatrics.2018; 61(4): 121. CrossRef - Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
Xin Wang, Bhramar Mukherjee, Sung Kyun Park
Environment International.2018; 121: 683. CrossRef - Toenail mercury and dyslipidemia: Interaction with selenium
Kyong Park, Eunmin Seo
Journal of Trace Elements in Medicine and Biology.2017; 39: 43. CrossRef - An analysis of factors affecting the mercury content in the human femoral bone
A. Zioła-Frankowska, M. Dąbrowski, Ł. Kubaszewski, P. Rogala, A. Kowalski, M. Frankowski
Environmental Science and Pollution Research.2017; 24(1): 547. CrossRef - Relationship between Selected Serum Metallic Elements and Obesity in Children and Adolescent in the U.S.
Yun Fan, Chunlan Zhang, Jin Bu
Nutrients.2017; 9(2): 104. CrossRef - Association between Blood Mercury Level and Visceral Adiposity in Adults
Seong-Su Moon
Diabetes & Metabolism Journal.2017; 41(2): 96. CrossRef - Association between Blood Mercury Level and Visceral Adiposity in Adults
Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim
Diabetes & Metabolism Journal.2017; 41(2): 113. CrossRef - Is mercury exposure causing diabetes, metabolic syndrome and insulin resistance? A systematic review of the literature
Cynthia Roy, Pierre-Yves Tremblay, Pierre Ayotte
Environmental Research.2017; 156: 747. CrossRef - Effects of biological factors and health condition on mercury and selenium concentrations in the cartilage, meniscus and anterior cruciate ligament
Danuta I. Kosik-Bogacka, Natalia Lanocha-Arendarczyk, Karolina Kot, Zaneta Ciosek, Pawel Zietek, Maciej Karaczun, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Joanna Podlasinska, Elzbieta Kalisinska, Joanna Pyzia
Journal of Trace Elements in Medicine and Biology.2017; 44: 201. CrossRef - The Association Between Blood Mercury Levels and Risk for Overweight in a General Adult Population: Results from the Korean National Health and Nutrition Examination Survey
Seunghyun Lee, Jin-Ha Yoon, Jong-Uk Won, Wanhyung Lee, June-Hee Lee, Hongdeok Seok, Yeong-Kwang Kim, Chi-Nyon Kim, Jaehoon Roh
Biological Trace Element Research.2016; 171(2): 251. CrossRef - Mercury as a possible link between maternal obesity and autism spectrum disorder
Anatoly V. Skalny, Margarita G. Skalnaya, Geir Bjørklund, Alexandr A. Nikonorov, Alexey A. Tinkov
Medical Hypotheses.2016; 91: 90. CrossRef - Cut-Off Values of Blood Mercury Concentration in Relation to Increased Body Mass Index and Waist Circumference in Koreans
Suhyun Bae, Soo-Jung Park, Kyung-Jin Yeum, Beomhee Choi, Young-Sang Kim, Nam-Seok Joo
Journal of Investigative Medicine.2016; 64(4): 867. CrossRef - Blood Mercury Can Be a Factor of Elevated Serum Ferritin: Analysis of Korea National Health and Nutrition Examination Survey (KNHANES 2008–2012)
Nam-Seok Joo, Young-Hwa Choi, Kyung-Jin Yeum, Soo-Jung Park, Beomhee Choi, Young-Sang Kim
Biological Trace Element Research.2015; 164(1): 3. CrossRef - Mercury and metabolic syndrome: a review of experimental and clinical observations
Alexey A. Tinkov, Olga P. Ajsuvakova, Margarita G. Skalnaya, Elizaveta V. Popova, Anton I. Sinitskii, Olga N. Nemereshina, Evgenia R. Gatiatulina, Alexandr A. Nikonorov, Anatoly V. Skalny
BioMetals.2015; 28(2): 231. CrossRef - The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007–2010
Sarah E. Rothenberg, Susan A. Korrick, Raja Fayad
Environmental Research.2015; 138: 173. CrossRef - Pb, Hg and Cd Concentration of Blood and Exposure-Related Factors
Jung-Sook Oh, Sun-Hee Lee
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(3): 2089. CrossRef - Population correlates of circulating mercury levels in Korean adults: the Korea National Health and Nutrition Examination Survey IV
Seongbeom Cho, David R Jacobs, Kyong Park
BMC Public Health.2014;[Epub] CrossRef - Reference levels of blood mercury and association with metabolic syndrome in Korean adults
Sang-Yong Eom, Sun-Hee Choi, Su-Ju Ahn, Dong-Kyeong Kim, Dong-Won Kim, Ji-Ae Lim, Byung-Sun Choi, Hye-Jung Shin, Sin-Weon Yun, Hae-Jung Yoon, Yu-Mi Kim, Young-Seoub Hong, Yong-Woon Yun, Seok-Joon Sohn, Heon Kim, Kyung-Su Park, Hee-Soo Pyo, Ho Kim, Se-Youn
International Archives of Occupational and Environmental Health.2014; 87(5): 501. CrossRef - Heavy Metal and Obesity
Sang Woo Oh
The Korean Journal of Obesity.2014; 23(1): 20. CrossRef - Relationship between blood mercury concentrations and serum γ-glutamyltranspeptidase level in Korean adults using data from the 2010 Korean National Health and Nutrition Examination Survey
Min-Seok Seo, Hye-Ree Lee, Jae-Yong Shim, Hee-Taik Kang, Yong-Jae Lee
Clinica Chimica Acta.2014; 430: 160. CrossRef - Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010
Seong-Su Moon
Endocrine.2014; 46(2): 263. CrossRef - Relationship between Blood Mercury Level and Risk of Cardiovascular Diseases: Results from the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) 2008-2009
Young-Nam Kim, Young A Kim, Ae-Ri Yang, Bog-Hieu Lee
Preventive Nutrition and Food Science.2014; 19(4): 333. CrossRef - Hair Mercury Levels in Periodontal Patients in Comparison with Healthy Individuals
Soraya Khafri, Hamidreza Hasanjani Roushan, Hadi Parsian, Ramin Alijannia, Abbas Mosapour
World Journal of Dentistry.2014; 5(3): 166. CrossRef - Association of lead, mercury and cadmium with diabetes in the Korean population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010
S.‐S. Moon
Diabetic Medicine.2013;[Epub] CrossRef - The Relationships Between Blood Mercury Concentration and Body Composition Measures Using 2010 Korean National Health and Nutrition Examination Survey
Dae-won Kang, Ka-young Lee
The Korean Journal of Obesity.2013; 22(4): 237. CrossRef - Prevalence of Unrecognized Lower Extremity Peripheral Arterial Disease and the Associated Factors in Chinese Hypertensive Adults
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The American Journal of Cardiology.2012; 110(11): 1692. CrossRef
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